Scientific Editor Profile
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Ian D., Ph.D.
Ian received his Bachelor of Veterinary Sciences degree (UK equivalent of DVM) with honors in 1992. He accepted a Laboratory Animal Medicine residency at the University of Alabama at Birmingham in 1994 where he also completed his PhD ("The role of
apoptosis in the pathogenesis of primate lentiviral infections") in 2000. Ian's research has been supported by the American Heart Association, the Cystic Fibrosis Foundation, NCRR, NIAID, NHLBI, and the Parker B. Francis Families Foundation. He chairs the Lung 1 Study Section for the American Heart Association and has reviewed grants for the NIAID, NIDOCD, and the Department of Defense. He also serves on three journal editorial boards and as an invited reviewer for multiple other journals in the fields of pulmonary medicine and influenza virology (including AJRCCM, Critical Care Medicine, Free Radical Biology, and Medicine, Journal of Virology, and PLoS Pathogens). As a reviewer, Ian's particular expertise relates to research involving animal models of lung function, viral and nonviral acute lung injury, viral exacerbations of chronic lung disorders, and respiratory epithelial cell biology.
Since 2001, Ian's primary research focus has been on the pathophysiologic effects of pulmonary viral infections (hantaviruses, respiratory syncytial virus, and influenza A viruses). He pioneered investigation of the impact of these pathogens on respiratory epithelial ion transport, alveolar fluid clearance, lung mechanics, and nucleotide signaling in vivo and developed novel techniques for measuring acute lung injury severity in mice. Over the past 9 years as an independent investigator, he extended his studies to focus on developing new therapeutics for viral acute lung injury, the pathogenesis of viral exacerbations of asthma and cystic fibrosis, and effects of viral infections on lung mechanics and pulmonary responses to ?-adrenergic agonists and glucocorticoids. He is currently studying the mechanistic role of alveolar type II (ATII) epithelial cells and alveolar macrophages in the pathogenesis of influenza-induced acute lung injury, using both murine and primary human airway epithelial cell models.